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Origami Size

For DNA nanostructures, choosing what class of structure to use depends on what size you want the origami to be. For <10 nm, small multi-strand complexes like tetrahedra1 are typically chosen. For nanostructures in the 100 nm range scaffolded origami are a common choice2. Within scaffolded origami, designers can retain size control by choosing scaffolds of different lengths3. Mini scaffolds can be prepared or purchased for origami in the 10–30 nm range. For structures >500 nm, two main approaches exist: hierarchical assembly of multi-origami complexes456 or DNA bricks7.

References

  1. Goodman, R. P. et al. Rapid Chiral Assembly of Rigid DNA Building Blocks for Molecular Nanofabrication. Science 310, 1661–1665 (2005).
  2. Rothemund, P. W. K. Folding DNA to create nanoscale shapes and patterns. Nature 440, 297–302 (2006).
  3. Brown, S. et al. An easy-to-prepare mini-scaffold for DNA origami. Nanoscale 7, 16621–16624 (2015).
  4. Tikhomirov, G., Petersen, P. & Qian, L. Fractal assembly of micrometre-scale DNA origami arrays with arbitrary patterns. Nature 552, 67–71 (2017).
  5. Wintersinger, C. M. et al. Multi-micron crisscross structures grown from DNA-origami slats. Nat. Nanotechnol. 18, 281–289 (2023).
  6. Wagenbauer, K. F., Sigl, C. & Dietz, H. Gigadalton-scale shape-programmable DNA assemblies. Nature 552, 78–83 (2017).
  7. Ke, Y., Ong, L. L., Shih, W. M. & Yin, P. Three-Dimensional Structures Self-Assembled from DNA Bricks. Science 338, 1177–1183 (2012).
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